The prophylaxis and treatment of malaria

Because malaria remains a major worldwide public health problem, and resistance to currently available drugs is becoming more prevalent, interest has focused on the clinical pharmacology of antimalarials. Previously many of these drugs had been little studied, and it is now hoped that increasing information on the disposition of current drugs, and those under development may improve their rational use. This article therefore reviews the current information on the pharmacology of the commoner drugs, and describes possible future tools to combat malaria.