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Neonatal Dermatologic Findings in Uruguay: Epidemiology and Predisposing Factors
M K De María1, K M Borda1, V N Arretche2
1Cátedra de Neonatología, Centro Hospitalario Pereira Rossell, Montevideo, Uruguay.
Insights
All newborns exhibit benign, transient skin findings as they adapt to life outside the womb. These common neonatal dermatologic characteristics vary based on factors like gestational age and ethnicity.
Area of Science:
- Neonatal Dermatology
- Pediatric Skin Health
- Infant Adaptation
Background:
- The skin plays a crucial role in a newborn's transition to extrauterine life.
- Neonatal infants commonly display benign, transient skin features influenced by maternal, gestational, and neonatal factors.
Purpose of the Study:
- To determine the prevalence of various dermatologic findings in newborns within the first 72 hours of life.
- To investigate associations between these skin findings and maternal, gestational, or neonatal factors.
Main Methods:
- A descriptive, observational, cross-sectional study was conducted.
- The skin of 2811 neonates was examined within 72 hours of birth.
- Statistical analysis was performed to calculate proportions, confidence intervals, and associations.
Main Results:
- All neonates presented with at least one skin finding; the median number of findings was 8.
- Common findings included lanugo (98%), physiological scaling (79.7%), and sebaceous hyperplasia (73.3%).
- Specific findings were associated with gestational age, sex, ethnicity, and delivery type.
Conclusions:
- Neonatal skin characteristics are normal adaptations to extrauterine life and are predominantly benign and transient.
- Factors such as maternal age, delivery method, gestational age, birth weight, sex, and ethnicity are linked to specific neonatal skin presentations.
Background:
The skin is a fundamental organ in the transition from intrauterine to extrauterine life. The newborn infant experiences physiological changes and often presents benign, transient skin characteristics that vary according to maternal, gestational, and neonatal factors.
Objectives:
To estimate the frequency of various dermatologic findings during the first 72hours of life and to identify their association with maternal, gestational, or neonatal factors.
Methods:
Descriptive, observational, cross-sectional study from April to July 2015 and July to November 2017 in the maternity ward of Centro Hospitalario Pereira Rossell. We examined the skin of neonates within 72hours of birth. Proportions and 95% CI were calculated for all findings. Associations between findings and factors were analyzed.
Results:
A total of 2811 neonates were included. We observed at least one neonatal skin finding in all of the neonates and found a median (interquartile range) of 8 (6-9) findings (minimum-maximum, 1-16). We observed 42 of the 46 possible characteristics we looked for; 99.9% of the findings were benign and transient. Among the findings were lanugo (98%; 95% CI, 97.7%-98.7%), physiological scaling (79.7%; 95% CI: 78.2%-81.1%), and sebaceous hyperplasia (73.3%; 95% CI: 71.6%-74.9%). Lanugo (P=.001), physiological scaling (P<.001), and erythema toxicum (P=.001) were observed significantly more often in full- and late-term neonates. Sebaceous hyperplasia (P=.001) and transient hyperpigmentation (P<.001) were found more often in newborn males. Erythema toxicum was more common after vaginal births (P=.008). Transient hyperpigmentation (P<.001) and dermal melanocytosis (P<.001) were seen more often in neonates of African descent.
Conclusions:
All neonates have skin characteristics that are part of their adaptation to extrauterine life. Most are benign and transient. Maternal age, type of delivery, and certain neonatal factors such as gestational age, birth weight, sex, and ethnicity are associated with specific findings.
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