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Infantile infection and antibiotic exposure in association with pediatric psoriasis development: A nationwide nested

Yi-Ju Chen1, Hsiu J Ho2, Chen-Yi Wu3

  • 1Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan; Faculty of Medicine and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Taiwan Microbiota Consortium, Taipei, Taiwan.

Journal of the American Academy of Dermatology
|December 15, 2020
PubMed

Insights

Early childhood skin infections, particularly fungal infections, are linked to pediatric psoriasis development. Systemic antibiotic exposure did not show a significant association in this study.

Area of Science:

  • Dermatology
  • Pediatrics
  • Epidemiology

Background:

  • Microbial dysbiosis and antibiotic use are suspected in pediatric inflammatory diseases.
  • Investigating early life factors for pediatric psoriasis is crucial.

Purpose of the Study:

  • To examine the impact of infantile infections and antibiotic exposure on pediatric psoriasis.
  • To identify risk factors for pediatric psoriasis development.

Main Methods:

  • Nationwide nested case-control study using Taiwan's National Health Insurance Research Database (2000-2017).
  • 1527 pediatric psoriasis cases matched with 15,270 controls.
  • Conditional logistic regression analysis to assess associations.

Main Results:

  • Atopic dermatitis and family history of psoriasis were significant risk factors.
  • Infantile skin infections (viral, bacterial, fungal) in the first two years were associated with pediatric psoriasis.
  • Systemic antibiotic exposure was not found to be associated.

Conclusions:

  • Early-life skin infections are associated with pediatric psoriasis.
  • Further research is needed to understand the role of microbial factors and antibiotic use.
Abstract

Keywords:
antibioticsinfantileinfectionmicrobiotanested case-control studypediatric psoriasis

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