Analysis of [11C]Choline and [13N]Ammonia using a single HPIC method
Huailei Jiang1, Ping Fang2, Mark S Jacobson2
1PET Radiochemistry Facility, Department of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Abstract:
A single HPIC method was developed and validated for the analysis of both [11C]Choline and [13N]Ammonia with the same setup. The HPIC system suitability tests were performed and [11C]Choline and [13N]Ammonia were used to verify their performance on this HPIC method. The HPIC setup and method provides qualitative and quantitative analysis information of [11C]Choline and [13N]Ammonia. The data suggested this HPIC method is validated for determining radiochemical/chemical purity and radiochemical identity of [11C]Choline and [13N]Ammonia products in CGMP compliant manufacturing process.
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