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Related Experiment Videos

Lactate metabolism.

J A Kruse1, R W Carlson

  • 1Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan.

Critical Care Clinics
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

Lactic acidosis, often caused by hypoperfusion and tissue hypoxia, indicates abnormal lactate levels. Direct blood lactate measurement is crucial for diagnosis and monitoring treatment effectiveness.

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Area of Science:

  • Biochemistry
  • Critical Care Medicine
  • Physiology

Background:

  • Lactate is the end product of anaerobic glucose metabolism.
  • Elevated blood lactate (hyperlactatemia) signifies increased production or decreased utilization.
  • Lactic acidosis commonly results from hypoperfusion, leading to tissue hypoxia.

Purpose of the Study:

  • To review the clinical recognition and management of hyperlactatemia and lactic acidosis.
  • To emphasize the importance of identifying underlying causes of elevated lactate.
  • To highlight the diagnostic and therapeutic monitoring role of blood lactate assays.

Main Methods:

  • Review of clinical settings associated with hyperlactatemia.
  • Evaluation of diagnostic utility of serum electrolytes and arterial blood gases.

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  • Emphasis on direct blood lactate assay for diagnosis and monitoring.

    • Main Results:

    • Hypoperfusion is the most frequent cause of lactic acidosis.
    • Many other hyperlactatemia causes are uncommon or linked to perfusion failure.
    • Blood lactate assays are essential for detecting, quantifying, and tracking treatment response.

    Conclusions:

    • Clinical awareness of specific settings aids hyperlactatemia recognition.
    • Direct lactate measurement is vital for accurate diagnosis and therapy monitoring.
    • Treatment should focus on improving oxygen delivery and addressing root causes.