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Ayurveda and Epigenetics.

Hari Sharma1, Robert Keith Wallace2

  • 1Ohio State Integrative Medicine, Department of Family and Community Medicine, College of Medicine, The Ohio State University, Columbus, OH 43221, USA.

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Summary

Epigenetics, the study of gene expression changes without altering DNA structure, may explain how Ayurveda influences health. This ancient Indian system addresses lifestyle and environmental factors, impacting gene activity across generations.

Keywords:
AyurvedaPrakritidoshasepigeneticsgenotypephenotype

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Area of Science:

  • Integrative Medicine
  • Genetics and Genomics
  • Ayurvedic Medicine

Background:

  • Ayurveda is a traditional Indian holistic health system.
  • Epigenetics involves modifications to DNA that regulate gene expression without changing the DNA sequence.
  • Epigenetic changes can be influenced by lifestyle, diet, stress, and environment, and may have transgenerational effects.

Purpose of the Study:

  • To propose epigenetics as a key mechanism underlying Ayurvedic practices.
  • To explore the correlation between Ayurvedic principles and epigenetic modifications.
  • To foster better integration between Ayurveda and modern medicine for health management.

Main Methods:

  • Conceptual analysis linking Ayurvedic principles to epigenetic factors.
  • Review of lifestyle, diet, stress, and environmental influences in Ayurveda.
  • Examination of how Ayurveda affects Deha Prakriti (phenotype) and Janma Prakriti (genotype) through epigenetic mechanisms.

Main Results:

  • Ayurveda's focus on lifestyle, diet, and stress management aligns with known epigenetic modulators.
  • Ayurvedic interventions may influence gene expression and heritable traits.
  • Epigenetics provides a scientific framework to understand Ayurvedic effects on health.

Conclusions:

  • Epigenetics offers a plausible biological mechanism for Ayurveda's efficacy.
  • Understanding this link can improve communication and integration between Ayurvedic and conventional medicine.
  • Further research into Ayurvedic modalities and gene expression is warranted.