Related Experiment Video
Updated: Nov 25, 2025

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography
Published on: January 17, 2025
Cognitive, Motor, and Language Development of Preschool Children With Craniofacial Microsomia
Brent R Collett1, Erin R Wallace2, Kathleen A Kapp-Simon3
1Department of Psychiatry and Behavioral Sciences, 7284University of Washington, Seattle, WA, USA.
Insights
Preschoolers with craniofacial microsomia (CFM) show similar cognitive and motor development as peers. However, language development may lag, indicating a need for early language monitoring and intervention in children with CFM.
Area of Science:
- Pediatric Neurodevelopment
- Craniofacial Anomalies
- Developmental Psychology
Background:
- Craniofacial microsomia (CFM) is a congenital condition affecting facial development.
- Neurodevelopmental outcomes in preschool-aged children with CFM require further investigation.
Purpose of the Study:
- To compare neurodevelopmental outcomes, specifically cognitive, motor, and language skills, in preschool-aged children with CFM versus unaffected peers.
- To identify potential developmental delays associated with CFM in early childhood.
Main Methods:
- A multisite, longitudinal cohort study included 92 children with CFM and 76 controls.
- Cognitive and motor skills were assessed using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III).
- Language function was evaluated using subtests from the Clinical Evaluation of Language Fundamentals-Preschool, second edition (CELF-P2).
Main Results:
- Cognitive and motor scores were comparable between children with CFM and controls (Bayley-III: ES = -0.06 to -0.19).
- Children with CFM demonstrated lower scores in language function compared to controls (CELF-P2: ES = -0.58 to -0.20).
- While developmental delay was more frequent in CFM cases (39% vs. 15%), this difference was not statistically significant.
Conclusions:
- Preschool-aged children with CFM exhibit similar cognitive and motor development but present with language deficits compared to their peers.
- Language assessment and early intervention are recommended for preschoolers diagnosed with CFM, particularly those with microtia or other facial features.
- These findings highlight the importance of targeted developmental surveillance in children with craniofacial anomalies.
Objective:
To examine neurodevelopment in preschool-aged children with craniofacial microsomia (CFM) relative to unaffected peers.
Design:
Multisite, longitudinal cohort study.
Setting:
Tertiary care centers in the United States.
Participants:
We included 92 children with CFM ("cases") through craniofacial centers and clinics. Seventy-six children without CFM (controls) were included from pediatric practices and community advertisements. This study reports on outcomes assessed when participants were an average age of 38.4 months (SD = 1.9).
Main Outcome Measures:
We assessed cognitive and motor skills using the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III), and language function using subtests from the Clinical Evaluation of Language Fundamentals-Preschool, second edition (CELF-P2).
Results:
Case-control differences were negligible for Bayley-III cognitive (effect sizes [ES] = -0.06, P = .72) and motor outcomes (ES = -0.19, P = .25). Cases scored lower than controls on most scales of the CELF-P2 (ES = -0.58 to -0.20, P = .01 to .26). Frequency counts for "developmental delay" (ie, one or more scores > 1 SD below the normative mean) were higher for cases (39%) than controls (15%); however, the adjusted odds ratio = 1.73 (P = 0.21) was not significant. Case-control differences were most evident in children with microtia or other combinations of CFM-related facial features.
Conclusions:
Cognitive and motor scores were similar for preschool-aged children with and without CFM. However, children with CFM scored lower than controls on language measures. We recommend early monitoring of language to identify preschoolers with CFM who could benefit from intervention.
More Related Videos
08:26Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
Published on: January 11, 2016
10:23Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
Published on: September 8, 2023
Related Concept Videos
Language and Cognition
Language Development
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
Three Developmental Domains
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
Piaget's Stage 1 of Cognitive Development
Exploration...
Higher Mental Functions of the Brain: Language
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Information Processing Approach