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Updated: Nov 25, 2025

A Protocol for Laboratory Housing of Turquoise Killifish Nothobranchius furzeri

A Protocol for Laboratory Housing of Turquoise Killifish Nothobranchius furzeri

Published on: April 11, 2018

Nothobranchius annual killifishes.

Eva Terzibasi Tozzini¹, Alessandro Cellerino^2,3

¹Stazione Zoologica "Anton Dohrn", Napoli, Italy.

|December 16, 2020

Summary

This summary is machine-generated.

The Nothobranchius furzeri, a short-lived fish, is a valuable model for aging research due to its rapid maturation and parallel evolution of lifespan. Its unique biology aids studies in aging and developmental biology.

Keywords:

Aging CRISPR/Cas9 Comparative genomics Diapause Extreme habitat Life history adaptation Neurodegeneration RNA-seq Teleost Transgenesis

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Protocol for Acute and Chronic Ecotoxicity Testing of the Turquoise Killifish Nothobranchius furzeri

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Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

Published on: August 9, 2022

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Last Updated: Nov 25, 2025

A Protocol for Laboratory Housing of Turquoise Killifish Nothobranchius furzeri

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Protocol for Acute and Chronic Ecotoxicity Testing of the Turquoise Killifish Nothobranchius furzeri

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Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

Published on: August 9, 2022

Area of Science:

Evolutionary biology
Gerontology
Developmental biology

Background:

Annual fishes (Nothobranchius) inhabit ephemeral African habitats, exhibiting rapid maturation, short lifespans, and embryonic diapause.
Nothobranchius furzeri is the fastest-maturing vertebrate with the shortest captive lifespan, making it a key model organism.
Extensive data exists on N. furzeri's phenotypes, ecology, distribution, and demography, alongside parallel evolution of lifespan in response to habitat precipitation.

Purpose of the Study:

To investigate the effects of genetic and non-genetic interventions on lifespan and aging phenotypes using N. furzeri.
To leverage N. furzeri for comparative studies in genomics, transcriptomics, and proteomics.
To explore the evolutionary and developmental biology of aging using a unique vertebrate model.

Main Methods:

Utilizing N. furzeri as a model organism for laboratory-based aging research.
Employing genome sequencing and CRISPR/Cas9 gene-editing techniques.
Conducting comparative analyses including genomics, transcriptomics, and proteomics.

Main Results:

N. furzeri exhibits rapid maturation and a short lifespan, ideal for aging studies.
Parallel evolution of lifespan and age-related traits observed across populations in different precipitation habitats.
Genome sequencing and gene-editing tools are established for N. furzeri.

Conclusions:

Nothobranchius furzeri is a powerful and expanding model organism for aging, evolutionary, and developmental biology research.
Its unique life history and genetic accessibility facilitate investigations into aging mechanisms and interventions.
Comparative approaches with N. furzeri offer insights into fundamental biological processes.