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Pathogenic Factors Correlate With Antimicrobial Resistance Among Clinical Proteus mirabilis Strains

Aneta Filipiak1, Magdalena Chrapek2, Elżbieta Literacka3

  • 1Department of Surgical Medicine with the Laboratory of Medical Genetics, Collegium Medicum, Jan Kochanowski University, Kielce, Poland.

Frontiers in Microbiology
|December 16, 2020
PubMed

Insights

Multidrug-resistant Proteus mirabilis strains show increased relatedness and biofilm formation. However, strong swarming motility in P. mirabilis correlates with antibiotic susceptibility, suggesting complex pathogenicity mechanisms.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Bacterial Pathogenesis

Background:

  • Proteus mirabilis is a significant cause of urinary tract infections (UTIs).
  • Key virulence factors include urease production, crystalline biofilm formation, and swarming motility.
  • Understanding the pathogenicity of antimicrobial-susceptible versus multidrug-resistant (MDR) P. mirabilis is crucial.

Purpose of the Study:

  • To compare the pathogenic properties of antimicrobial-susceptible and MDR clinical P. mirabilis isolates from Poland.
  • To investigate correlations between virulence factors, genetic relatedness, and antibiotic resistance profiles.

Main Methods:

  • Analysis of virulence gene profiles.
  • Assessment of urease and hemolysin production.
  • Evaluation of biofilm formation and swarming motility.
  • Dienes test for strain relatedness and antibiotic susceptibility testing.

Main Results:

  • MDR P. mirabilis strains exhibited greater genetic relatedness compared to susceptible strains.
  • Stronger biofilm formation correlated with broader antimicrobial resistance.
  • Enhanced swarming motility was associated with susceptibility to most antibiotics.

Conclusions:

  • Distinct pathogenic profiles exist between susceptible and MDR P. mirabilis clinical isolates.
  • The interplay between biofilm, swarming, and MDR status warrants further investigation.
  • Findings highlight the complexity of P. mirabilis pathogenicity mechanisms.
Keywords:
P. mirabilisantimicrobial resistancebiofilmpathogenic factorsswarming motility

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