Related Experiment Video
Updated: Nov 25, 2025

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
Published on: May 14, 2019
Exosomal circRNAs: Sorting Mechanisms, Roles and Clinical Applications in Tumors
Yanhua Xu1,2,3, Shan Kong1,2,3, Shiyi Qin1,2,3
1Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Abstract:
Exosomes are a group of nano-sized membrane vesicles and are important mediators of intercellular communication, particularly in tumor microenvironment. Recently, researchers have found that circular RNAs (circRNAs), with the great research significance, are enriched and stable in exosomes. In this review, we summarize the research significance of exosomal circRNAs, sorting mechanisms and their functioning mechanisms in tumor progression. Their clinical applications as clinical tumor biomarkers and as therapeutic targets in inhibiting tumor metastasis, anti-cancer immunity response and drug resistance have been widely discussed.
Related Concept Videos
Overview of Exosomes
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
The Early Endosome: Endocytosis of Transferrin
Regulation of Nuclear Protein Sorting

