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Autoimmune Gastritis Treated With Mycophenolate Mofetil
Ali H Harb1, Roopa Vemulapalli1, Purva Gopal2
1Division of Gastroenterology, University of Texas Southwestern Medical Center, Dallas, TX.
ACG Case Reports Journal
|December 16, 2020
Summary
Autoimmune gastritis, an inflammation of the stomach lining, can cause chronic pain. Mycophenolate mofetil effectively resolved symptoms and inflammation in a patient refractory to other treatments.
Area of Science:
- Gastroenterology
- Immunology
- Internal Medicine
Background:
- Autoimmune gastritis involves chronic inflammation of the gastric mucosa.
- It can lead to persistent gastrointestinal symptoms.
- Standard treatments may not always be effective.
Observation:
- A 64-year-old woman presented with a 3-year history of chronic abdominal pain.
- Endoscopic and histologic findings confirmed autoimmune pangastritis.
- The patient experienced partial response to steroids but failed other immunosuppressants.
Findings:
- Treatment with mycophenolate mofetil led to complete symptom resolution.
- Follow-up examinations showed near-complete resolution of active gastric inflammation.
- This represents the first reported case of successful mycophenolate mofetil treatment for symptomatic autoimmune gastritis.
Implications:
- Mycophenolate mofetil is a potential therapeutic option for refractory autoimmune gastritis.
- This finding expands treatment possibilities for patients with autoimmune gastritis.
- Further research is warranted to evaluate mycophenolate mofetil's efficacy in a larger cohort.
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