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Long-term safety of prenatal and neonatal exposure to paracetamol: a protocol for a systematic review

Samira Samiee-Zafarghandy1, Katelyn Sushko2, John Van Den Anker3,4

  • 1Department of Pediatrics, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada.

BMJ Paediatrics Open
|December 16, 2020
PubMed

Insights

This systematic review examines the long-term safety of paracetamol (acetaminophen) in newborns following prenatal and neonatal exposure. It aims to consolidate evidence on potential adverse events for better clinical guidance.

Area of Science:

  • Neonatal pharmacology and toxicology
  • Evidence synthesis and systematic reviews
  • Pediatric long-term health outcomes

Background:

  • Increasing use of paracetamol in neonates raises safety concerns.
  • Potential for long-term adverse events from prenatal and neonatal paracetamol exposure.
  • Need for a comprehensive review of existing evidence.

Approach:

  • Systematic review following Joanna Briggs Institute and PRISMA guidelines.
  • Comprehensive literature search across Embase, MEDLINE, Web of Science, and Google Scholar.
  • Inclusion of studies regardless of language or design, with rigorous risk of bias assessment.

Key Points:

  • Focus on long-term adverse events in infants exposed to paracetamol.
  • Systematic synthesis of data from diverse study designs.
  • Quality assessment to ensure reliability of findings.

Conclusions:

  • This review will provide critical insights into the long-term safety profile of neonatal paracetamol exposure.
  • Findings will inform clinical practice and future research directions.
  • Dissemination through peer-reviewed publications and scientific conferences.
Abstract

Keywords:
neonatologypharmacology

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