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First Report of Fatal Infection Caused by Community-acquired Methicillin-resistant Staphylococcus aureus USA300 Clone

Ryohei Yokomori1, Junya Tsurukiri1, Mariko Moriya1

  • 1Emergency and Critical Care Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.

JMA Journal
|December 16, 2020
PubMed

Insights

A rare case of severe Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 infection occurred in a Japanese athlete. This study highlights the potential for life-threatening CA-MRSA infections, including sepsis and septic pulmonary emboli.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) causes skin and soft tissue infections globally.
  • Panton-Valentine leukocidin (PVL)-positive CA-MRSA strains are associated with severe, life-threatening infections like septic pulmonary emboli (SPE) and infectious endocarditis.
  • Severe PVL-positive CA-MRSA infections are infrequently reported in Japan.

Observation:

  • A 20-year-old Japanese college athlete presented with severe infections.
  • The patient had infections including sepsis, SPE, and skin and soft tissue infections.
  • Iliofemoral deep venous thrombosis was also present.

Findings:

  • This case represents the first reported instance of a life-threatening PVL-positive CA-MRSA USA300 clone infection in Japan.
  • The infection manifested as sepsis, SPE, and extensive skin and soft tissue involvement with deep vein thrombosis.

Implications:

  • This case underscores the emergence of virulent CA-MRSA strains like USA300 in Japan.
  • It highlights the need for increased awareness and diagnostic vigilance for severe CA-MRSA infections in clinical practice.
  • Early recognition and management are crucial for improving outcomes in patients with PVL-positive CA-MRSA infections.
Keywords:
USA300 cloneacute respiratory distress syndromebacteremiacommunity-acquired methicillin-resistant Staphylococcus aureussepsis

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