Cognitive impairment in children with chronic Hepatitis C Virus: Case control study
Ibtihal Ma Ibrahim1, Amal Haikal1, Khadiga M Ali2
1Psychiatry Department, Mansoura Faculty of medicine, Mansoura University, Mansoura, Egypt.
Clinical Child Psychology and Psychiatry
|December 16, 2020
Summary
Children with Hepatitis C virus (HCV) infection show cognitive impairment linked to depression and liver inflammation. Social class also impacts cognitive function in these pediatric patients.
Area of Science:
- Pediatric Hepatology
- Child Psychology
- Infectious Diseases
Background:
- Hepatitis C virus (HCV) is a leading cause of chronic liver disease in children.
- Cognitive and psychological impacts of HCV in pediatric populations require further investigation.
Purpose of the Study:
- To compare cognitive impairment and psychological status in treatment-naïve children with HCV against a control group.
- To identify predictors of cognitive impairment in pediatric HCV patients.
Main Methods:
- Recruitment of 102 treatment-naïve children with HCV and matched controls (ages 7-17).
- Assessment of cognitive functioning, behavior, depression, and anxiety.
- Inclusion of laboratory investigations and liver biopsy for disease activity evaluation.
Main Results:
- Depression scores correlated negatively with liver biopsy activity and positively with white blood cell count (WBCS).
- Anxiety scores positively correlated with WBCS.
- Cognitive scores (Verbal IQ, Performance IQ, Total IQ) correlated with social class and liver biopsy activity. Higher depression predicted lower verbal IQ.
Conclusions:
- Depression, social class, and liver inflammation are significant predictors of cognitive impairment in children with HCV.
- Psychological and socio-economic factors play a crucial role in the cognitive health of pediatric HCV patients.
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