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Cognitive impairment in children with chronic Hepatitis C Virus: Case control study

Ibtihal Ma Ibrahim1, Amal Haikal1, Khadiga M Ali2

  • 1Psychiatry Department, Mansoura Faculty of medicine, Mansoura University, Mansoura, Egypt.

Clinical Child Psychology and Psychiatry
|December 16, 2020
PubMed

Insights

Children with Hepatitis C virus (HCV) infection show cognitive impairment linked to depression and liver inflammation. Social class also impacts cognitive function in these pediatric patients.

Area of Science:

  • Pediatric Hepatology
  • Child Psychology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) is a leading cause of chronic liver disease in children.
  • Cognitive and psychological impacts of HCV in pediatric populations require further investigation.

Purpose of the Study:

  • To compare cognitive impairment and psychological status in treatment-naïve children with HCV against a control group.
  • To identify predictors of cognitive impairment in pediatric HCV patients.

Main Methods:

  • Recruitment of 102 treatment-naïve children with HCV and matched controls (ages 7-17).
  • Assessment of cognitive functioning, behavior, depression, and anxiety.
  • Inclusion of laboratory investigations and liver biopsy for disease activity evaluation.

Main Results:

  • Depression scores correlated negatively with liver biopsy activity and positively with white blood cell count (WBCS).
  • Anxiety scores positively correlated with WBCS.
  • Cognitive scores (Verbal IQ, Performance IQ, Total IQ) correlated with social class and liver biopsy activity. Higher depression predicted lower verbal IQ.

Conclusions:

  • Depression, social class, and liver inflammation are significant predictors of cognitive impairment in children with HCV.
  • Psychological and socio-economic factors play a crucial role in the cognitive health of pediatric HCV patients.

Keywords:
HCVanxietychildrencognitiondepressionliver biopsy

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