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Postnatally acquired CMV meningitis diagnosed via BioFire FilmArray: A case report

A Stark1, J Peterson1, K Weimer1

  • 1Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.

Journal of Neonatal-Perinatal Medicine
|December 16, 2020
PubMed

Insights

Postnatal cytomegalovirus (CMV) meningitis is rare in premature infants. The BioFire FilmArray rapidly diagnosed CMV meningitis in a very low birth weight infant, enabling faster treatment.

Area of Science:

  • Neonatal infectious diseases
  • Clinical microbiology
  • Diagnostic technology

Background:

  • Postnatal cytomegalovirus (CMV) infection is common in premature infants, often acquired through breast milk.
  • CMV infection can manifest as meningitis, a rare but serious condition, particularly challenging to diagnose in preterm neonates.
  • Current diagnostic methods for meningitis are slow, leading to prolonged empiric antibiotic use.

Observation:

  • A very low birth weight infant presented with symptoms suggestive of meningitis.
  • The infant had postnatally acquired cytomegalovirus (CMV) infection.
  • Diagnosis was challenging due to the infant's preterm status and rarity of CMV meningitis.

Findings:

  • The BioFire FilmArray (BFA), a multiplex PCR panel, was utilized for rapid pathogen detection.
  • BFA identified cytomegalovirus (CMV) in the cerebrospinal fluid (CSF).
  • This enabled a swift diagnosis of CMV meningitis, confirmed as the first such case diagnosed via BFA.

Implications:

  • The BioFire FilmArray offers a significant advantage in the rapid diagnosis of CNS infections in neonates.
  • Quicker diagnosis of CMV meningitis can lead to earlier targeted treatment, potentially improving outcomes.
  • This case highlights the utility of advanced molecular diagnostic tools in managing rare neonatal infections.
Keywords:
Postnatally acquired cytomegalovirusbiofire filmarraymeningitisprematurity

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