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Related Experiment Video

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Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay
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X-box binding protein 1 (XBP1) function in diseases.

Wenjing Xu1, Congrong Wang2, Jinlian Hua1

  • 1Shaanxi Centre of Stem Cells Engineering & Technology, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.

Cell Biology International
|December 16, 2020
PubMed
Summary
This summary is machine-generated.

The unfolded protein response (UPR) pathway, specifically IRE1-XBP1, is crucial for cell survival during endoplasmic reticulum stress (ERS). Its dysregulation impacts diseases and male reproduction.

Keywords:
ER stressIRE1αXBP1disease

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Area of Science:

  • Molecular Biology
  • Cellular Stress Response
  • Disease Pathogenesis

Background:

  • Endoplasmic reticulum stress (ERS) arises from unfolded/misfolded proteins, impacting high-secretion cells.
  • The unfolding protein response (UPR) is a cellular adaptive mechanism to ERS, promoting homeostasis and survival.
  • Prolonged ERS can trigger apoptosis, highlighting the critical role of UPR pathways.

Purpose of the Study:

  • To review the latest research on the IRE1-XBP1 pathway in cancer and metabolic diseases.
  • To analyze the relationship between the IRE1-XBP1 pathway and various disease states.
  • To explore the role and prospects of the IRE1-XBP1 pathway in male reproduction.

Main Methods:

  • Literature review of recent studies on the IRE1-XBP1 signaling pathway.
  • Analysis of the pathway's involvement in cancer, metabolic, and other diseases.
  • Synthesis of current understanding regarding IRE1-XBP1's regulation of male reproduction.

Main Results:

  • The IRE1-XBP1 pathway is a highly conserved UPR branch vital in physiological and pathological conditions.
  • IRE1-XBP1 activity significantly influences disease progression and patient prognosis.
  • Emerging evidence links IRE1-XBP1 to male reproductive functions.

Conclusions:

  • The IRE1-XBP1 pathway is a key regulator in cellular adaptation to ERS and disease development.
  • Understanding IRE1-XBP1's multifaceted roles offers therapeutic potential for various diseases.
  • Further research into IRE1-XBP1's impact on male reproduction is warranted.