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Six 19,20-epoxycytochalasans from endophytic Diaporthe sp. RJ-47
Qiong Zhang1, Zhi-Pu Huang1, Yu-Ying Zhao1
1College of Basic Medicine, College of Chinese Material Medical, Yunnan University of Chinese Medicine, Kun Ming, P. R. China.
Abstract:
Two new cytochalasins, deacetyl-19-epi-cytochalasin P1 (1), deacetyl-19,20-epoxycytochalasin D (2) were isolated from the endophytic fungus Diaporthe sp. RJ-47, along with four known compounds deacetyl-5,6-dihydro-7-oxo-19,20-epoxycytochalasin C (3), 19,20-epoxycytochalasin Q (4), 19,20-epoxycytochalasin C (5) and deacetyl-19,20-epoxy cytochalasin C (6). Their structures were unambiguously elucidated on the basis of the comprehensive analysis of extensive spectroscopic data. The antimicrobial effects of these compounds were evaluated.
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