Related Experiment Video

Updated: Nov 25, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.5K

Migraine in Children Under 7 Years of Age: a Review

Vincenzo Raieli1, Antonina D'Amico2, Ettore Piro3

  • 1Child Neuropsychiatry Unit- ISMEP -P.O. Cristina - ARNAS Civico, via dei Benedettini 1, Palermo, Italy. vraieli@libero.it.

Current Pain and Headache Reports
|December 16, 2020
PubMed

Insights

Migraine is common in children under 7, presenting unique clinical and therapeutic challenges. Early identification and management are crucial due to potential long-term negative impacts.

Area of Science:

  • Neurology
  • Pediatrics
  • Epidemiology

Background:

  • Pediatric headache research is extensive, yet data on children under 7 remain limited.
  • Migraine affects up to 4% of the general pediatric population, but prevalence may be underestimated in younger children.
  • Challenges in diagnosing migraine in young children include difficulty describing pain and reliance on parental reports.

Purpose of the Study:

  • To provide a comprehensive review of the epidemiologic, clinical, and therapeutic aspects of migraine in children under 7 years of age.
  • To highlight the unique characteristics of migraine in this specific age group compared to older children.
  • To discuss the potential role of prenatal and perinatal factors in migraine development.

Main Methods:

  • Literature review of existing studies on pediatric migraine.
  • Analysis of clinical presentation and therapeutic approaches in children under 7.
  • Exploration of epidemiological data and diagnostic challenges.

Main Results:

  • Migraine in children under 7 exhibits distinct clinical and therapeutic differences from older age groups.
  • Early-onset migraine may negatively influence its natural course, underscoring the need for early intervention.
  • Prenatal and perinatal factors may predispose children to or anticipate the onset of migraine.

Conclusions:

  • Migraine is not rare in children under 7 and presents a significant clinical challenge.
  • Early identification and management of migraine in young children are recommended.
  • Further research is needed to address undefined features of migraine in this population.
Abstract

Keywords:
ChildrenEmbryo-fetal developmentMigrainePediatric headachePreschoolers

More Related Videos

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.5K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.1K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
109
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
110
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
110
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
90
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.7K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
135