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Initial experience with percutaneous mitral valve repair in patients with cardiac amyloidosis

Martin J Volz1, Sven T Pleger1, Andreas Weber1

  • 1Division of Cardiology, Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.

European Journal of Clinical Investigation
|December 16, 2020
PubMed
Abstract

Insights

Percutaneous mitral valve repair (PMVR) is safe and effective for severe mitral regurgitation in cardiac amyloidosis patients. This procedure may offer a survival benefit compared to no intervention.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Amyloidosis Research

Background:

  • Severe mitral regurgitation (MR) impacts heart failure patients.
  • Limited data exists on percutaneous mitral valve repair (PMVR) safety and efficacy in cardiac amyloidosis.

Purpose of the Study:

  • To evaluate the safety and efficacy of PMVR in patients with cardiac amyloidosis and severe MR.
  • To compare outcomes of PMVR versus no intervention in this patient population.

Main Methods:

  • Retrospective analysis of five patients with cardiac amyloidosis undergoing PMVR.
  • Comparison with seven control patients with cardiac amyloidosis not receiving PMVR.
  • Assessment of clinical, functional, renal, and biomarker data; evaluation of MR reduction and survival at 12 months.

Main Results:

  • PMVR demonstrated 100% procedural, technical, and device success.
  • Significant reduction in MR was observed at 12 months (P=.038).
  • The PMVR group showed a potential survival benefit compared to the control group (P=.02).

Conclusions:

  • PMVR is a feasible and safe intervention for cardiac amyloidosis patients with severe MR.
  • The procedure may be associated with improved survival in this high-risk group.
Keywords:
amyloid cardiomyopathycardiac amyloidosismitral regurgitationpercutaneous mitral valve repair

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