Related Experiment Video
Updated: Nov 25, 2025
08:49
Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
Published on: March 18, 2020
11.4K
CD57+ Memory T Cells Proliferate In Vivo
Raya Ahmed1, Kelly L Miners2, Julio Lahoz-Beneytez3
1Institute for Infection and Immunity, St. George's, University of London, London SW17 0RE, UK.
Cell Reports
|December 16, 2020
Summary
Senescent memory T cells expressing CD57 are sustained by self-renewal, not just phenotypic transition. This finding suggests that immunological memory is intrinsically sustainable in aged, differentiated T cell populations.
Area of Science:
- Immunology
- Cell Biology
- Aging Research
Background:
- A central tenet in lymphocyte biology is that memory T cells expressing CD57 are replicatively senescent.
- These CD57+ memory T cells accumulate with age and expand during persistent antigen stimulation.
Purpose of the Study:
- To investigate the origin of CD57+ memory T cells.
- To determine whether CD57+ memory T cells arise from phenotypic transition or self-renewal through proliferation.
Main Methods:
- In vivo deuterium labeling to track cell division.
- Ex vivo analysis of telomere length and telomerase activity.
- Intracellular Ki67 expression to assess cell proliferation.
Main Results:
- Compelling evidence supports the self-renewal of CD57+ memory T cells via intracompartmental proliferation.
- Mathematical modeling indicates self-renewal is the primary source of new CD57+ memory T cells.
- These findings challenge the notion that CD57+ cells are exclusively terminally differentiated and non-proliferative.
Conclusions:
- Immunological memory is intrinsically sustainable within highly differentiated T cell subsets expressing CD57.
- The self-renewal capacity of CD57+ memory T cells contributes significantly to maintaining immune memory over time.
Keywords:
Enter keywords here
Related Concept Videos
01:23Cells of the Adaptive Immune Response
7.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.5K
01:22T Cell Activation and Clonal Selection
14.1K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
14.1K
01:23Immunological Memory
14.4K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.4K
01:27Cytotoxic T Cells-mediated Immune Response
6.1K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.1K