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Iron deficiency for prognosis in acute coronary syndrome - A systematic review and meta-analysis

Johannes Reinhold1, Charikleia Papadopoulou2, Ranu Baral1

  • 1University of East Anglia (UEA), Norwich Research Park, Norwich NR4 7TJ, United Kingdom; Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, United Kingdom.

International Journal of Cardiology
|December 16, 2020
PubMed

Insights

Iron deficiency (ID) is common in acute coronary syndrome (ACS) patients. While short-term outcomes vary, ID may predict worse long-term prognosis in ACS, suggesting a treatable factor for patient management.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Research

Background:

  • Iron deficiency (ID) is linked to poor outcomes in heart failure.
  • The prognostic impact of ID in acute coronary syndrome (ACS) remains unclear.

Purpose of the Study:

  • To evaluate the prognostic significance of iron deficiency in patients diagnosed with acute coronary syndrome (ACS).

Main Methods:

  • Systematic review and meta-analysis of cohort studies.
  • Searched PubMed, Web of Science, and Cochrane Library for studies on ACS patients stratified by ID status.
  • Included 7 studies with 2821 participants, with data extraction and appraisal by two independent reviewers.

Main Results:

  • A high prevalence of iron deficiency was observed in the ACS population.
  • Three studies indicated worse long-term outcomes for patients with ID.
  • Short-term outcomes showed heterogeneity across the included studies.

Conclusions:

  • Iron deficiency in ACS patients may be associated with a poorer long-term prognosis.
  • Further research is needed to confirm the prognostic role of ID in ACS.
  • ID in ACS could be a treatable condition with implications for patient management.
Abstract

Keywords:
Acute coronary syndromeIron deficiencyMeta-analysisMyocardial infarctionPrognosis

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