Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glial repair in an insect.

J E Treherne1, E A Howes, P J Smith

  • 1AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, Cambridge, U.K.

Journal De Physiologie
|January 1, 1987
PubMed
Summary

Cockroach central nervous system repair involves unique cells from haemocytes invading lesions. These cells initiate repair and transform into functional glia, mirroring vertebrate brain repair processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The distribution of an intertidal aphid, Pemphigus trehernei foster, on marine saltmarshes.

Oecologia·2017
Same author

Short-term changes in activity rhythms in an intertidal arthropod (Acarina: Bdella interrupta Evans).

Oecologia·2017
Same author

Reproductive behaviour of the ocean skater Halobates robustus (Hemiptera: Gerridae) in the Galapagos Islands.

Oecologia·2017
Same author

Actin and actin-binding proteins in bovine spermatozoa: potential role in membrane remodeling and intracellular signaling during epididymal maturation and the acrosome reaction.

Journal of andrology·2001
Same author

Cellular distribution and molecular heterogeneity of MAC393 antigen (clusterin, beta-chain) on the surface membrane of bull spermatozoa.

Molecular human reproduction·1998
Same author

Expression of a testis-specific putative actin-capping protein associated with the developing acrosome during rat spermiogenesis.

Molecular reproduction and development·1997

Area of Science:

  • Neuroscience
  • Insect Biology
  • Cell Biology

Background:

  • Glial cells are crucial for the central nervous system's (CNS) function and integrity.
  • Understanding glial repair mechanisms is vital for regenerative medicine and neuroscience.
  • Insect models offer valuable insights into fundamental biological processes, including neural repair.

Purpose of the Study:

  • To investigate the cellular mechanisms underlying the repair of damaged cockroach central nervous system connectives.
  • To identify the origin and role of cells involved in glial repair following injury.
  • To compare insect glial repair processes with those observed in vertebrate brains.

Main Methods:

  • Selective disruption of glial cells in cockroach central nervous connectives.
  • Utilizing monoclonal antibodies to trace cell origins.
  • Microscopic analysis to observe cell invasion, proliferation, and transformation within the lesion zone.
  • Time-course analysis of cellular changes over several days post-injury.

Main Results:

  • A novel class of cells, originating from circulating haemocytes, invades the lesion site.
  • These exogenous cells initiate the repair of peripheral glial elements and recruit endogenous reactive cells.
  • A distinct anterior polarity in cell recruitment was observed.
  • Exogenous cells decline after 3 days, transforming into or being replaced by functional perineurial glia.
  • Blood-brain barrier restoration and endogenous cell division coincide with this transformation.

Conclusions:

  • Glial repair in the insect CNS is a multi-phase process involving exogenous cell invasion, proliferation, and transformation.
  • The identified repair sequence shows remarkable parallels with glial repair mechanisms in the vertebrate brain.
  • Haemocyte-derived cells play a pivotal role in initiating and executing CNS repair in insects.

Related Experiment Videos