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Finite Element Modelling of a Cellular Electric Microenvironment

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Community effects allow bioelectrical reprogramming of cell membrane potentials in multicellular aggregates: Model

Javier Cervera¹, Patricio Ramirez², Michael Levin³

¹Departamento Termodinàmica, Universitat de València, E-46100 Burjassot, Spain.

Physical Review. E

|December 17, 2020

Summary

Bioelectrical patterns in cell aggregates can be stabilized by intercellular coupling. These community effects allow for reprogramming of cell states, crucial for development and regeneration.

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Area of Science:

Biophysics
Developmental Biology
Computational Biology

Background:

Bioelectrical patterns, arising from cell membrane potentials, are vital for multicellular processes like development and regeneration.
Understanding how local cell populations interact within larger aggregates is key to deciphering complex biological functions.

Purpose of the Study:

To investigate the conditions under which a small patch of cells with a distinct bioelectrical state can be stabilized within a larger aggregate.
To explore how intercellular coupling influences bioelectrical community effects and pattern formation in multicellular systems.

Main Methods:

Multicellular simulations were performed to model bioelectrical community effects and intercellular coupling.
A model incorporating two generic voltage-gated ion channels and variable coupling conductances was used to simulate polarized and depolarized cell states.

Main Results:

Community effects are regulated at both single-cell and intercellular levels, dependent on the balance of intercellular coupling within the patch, bulk, and at their interface.
Simulations suggest that bioelectrical community effects can lead to the reprogramming of individual cell bioelectrical states.
The study identified conditions for stabilizing local bioelectrical heterogeneities within multicellular aggregates.

Conclusions:

The balance of intercellular coupling is critical for establishing stable bioelectrical patterns and regionalization in multicellular systems.
Findings support the potential for electroceutical interventions to correct abnormal bioelectrical states in tissues.
This research provides insights into biophysical mechanisms for engineering target bioelectrical patterns in multicellular constructs.