Related Experiment Video

Updated: Nov 25, 2025

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

19.9K

Copeptin levels predict left ventricular systolic function in STEMI patients: A 2D speckle tracking

Hilal Erken Pamukcu1, Mehmet Ali Felekoğlu1, Engin Algül2

  • 1Department of Cardiology, University of Health Sciences Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara.

Medicine
|December 17, 2020
PubMed

Insights

Admission copeptin levels predict left ventricle (LV) systolic function in ST-segment elevation myocardial infarction (STEMI) patients. Higher copeptin correlates with poorer LV systolic function and less improvement over six months.

Area of Science:

  • Cardiology
  • Biomarkers
  • Echocardiography

Background:

  • ST-segment elevation myocardial infarction (STEMI) poses significant risks to left ventricle (LV) systolic function.
  • Early identification of patients at risk for impaired LV function is crucial for timely intervention.
  • Copeptin, a marker of stress, has been investigated for its prognostic value in cardiovascular diseases.

Purpose of the Study:

  • To investigate the association between admission copeptin levels and LV systolic function in STEMI patients.
  • To assess the relationship between copeptin and the improvement of LV systolic function at 6-month follow-up.
  • To determine if copeptin can predict early and long-term LV systolic function in STEMI.

Main Methods:

  • A prospective observational study included 122 STEMI patients.
  • LV systolic function was assessed using global longitudinal strain (GLS) and conventional echocardiography on admission and at 6 months.
  • Serum copeptin levels were measured using an ultrasensitive immunofluorescence assay.

Main Results:

  • Patients with high admission copeptin levels showed significantly lower GLS at both early stage and 6 months compared to those with low copeptin.
  • Copeptin levels were negatively correlated with early and 6-month GLS.
  • Admission copeptin levels were also negatively correlated with the improvement of GLS at 6-month follow-up.

Conclusions:

  • Admission serum copeptin levels can predict early and 6-month LV systolic function in STEMI patients, as assessed by GLS.
  • This study is the first to specifically link copeptin values with GLS in the context of STEMI.
  • Copeptin may serve as a valuable biomarker for assessing LV systolic function and recovery post-STEMI.

More Related Videos

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

24.5K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.3K

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
94