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Congenital Heart Disease in Non-Diabetic Large-for-Gestational-Age (LGA) Neonates

Majid Firouzi1, Hamidreza Sherkatolabbasieh1, Alireza Nezami1

  • 1Department of Pediatrics, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Cardiovascular & Hematological Disorders Drug Targets
|December 17, 2020
PubMed

Insights

Neonates with large for gestational age, often called macrosomic infants, have a higher risk of congenital heart disease. Arterial septal defect was the most common anomaly found in this study.

Area of Science:

  • Neonatal health
  • Pediatric cardiology
  • Congenital abnormalities

Background:

  • Congenital heart diseases (CHDs) are the most common birth defects in neonates.
  • CHDs are a leading cause of infant mortality.
  • Both environmental and genetic factors contribute to CHD development.

Purpose of the Study:

  • To investigate the association between large for gestational age (LGA) neonates and the risk of congenital heart diseases.
  • To evaluate this relationship specifically in non-diabetic mothers.

Main Methods:

  • A cohort of 179 LGA neonates in Khorramabad were enrolled.
  • Echocardiography was used to screen for heart abnormalities in all neonates.
  • Statistical analysis was performed to determine significant relationships.

Main Results:

  • 92 (51%) of the LGA neonates had congenital heart diseases.
  • A significant relationship was found between high birth weight (macrosomia) and increased CHD risk.
  • Arterial septal defect (ASD) was the most prevalent anomaly (38%), followed by ASD and Ventricular Septal Defect (VSD) (15.2%).

Conclusions:

  • Macrosomia in neonates is significantly associated with an increased risk of congenital heart disease.
  • Arterial septal defect is the most common CHD in LGA neonates.
  • Further research is recommended to explore the link between neonatal birth weight and CHDs.
Abstract

Keywords:
Congenital heart abnormalitiesbirth weightheart abnormalities.large for gestational agematernal ageneonatal

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