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Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

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Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Raffaella Di Micco1, Valery Krizhanovsky2, Darren Baker3,4

  • 1San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy. dimicco.raffaella@hsr.it.

Nature Reviews. Molecular Cell Biology
|December 17, 2020
PubMed

Insights

Cellular senescence, a state of irreversible cell cycle arrest, contributes to aging and disease. Targeting senescent cells with senolytic or senomorphic therapies offers a promising approach to combat age-related conditions.

Area of Science:

  • Gerontology
  • Cell Biology
  • Biotechnology

Background:

  • Cellular senescence, a state of permanent cell proliferation arrest, is triggered by various stresses and plays roles in development and aging.
  • Senescent cells secrete factors (senescence-associated secretory phenotype) that impair tissue repair and drive age-related diseases.

Purpose of the Study:

  • To review the mechanisms of cellular senescence establishment and the induction of the senescence-associated secretory phenotype.
  • To provide an overview of cellular senescence as a therapeutic target for aging and age-associated diseases.

Main Methods:

  • Literature review of cellular senescence mechanisms.
  • Analysis of senescence-associated secretory phenotype induction.
  • Overview of senolytic and senomorphic therapeutic strategies.

Main Results:

  • Cellular senescence is a complex process with implications in development, aging, and disease.
  • The senescence-associated secretory phenotype significantly contributes to tissue dysfunction and aging.
  • Senolytic and senomorphic therapies show potential for intervening in aging and related diseases.

Conclusions:

  • Cellular senescence is a critical factor in aging and age-associated diseases.
  • Targeting senescent cells offers a novel therapeutic avenue for improving healthspan and treating age-related pathologies.

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