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Continued Dosing of Oritavancin for Complicated Gram-Positive Infections

Jodi Meyer1, Paul Lata1, Susanne Barnett1

  • 1is a Doctor of Pharmacy candidate, and is an Associate Professor of Pharmacy, both at the University of Wisconsin. and Susanne Barnett are Clinical Pharmacists at William S. Middleton Memorial Veterans Hospital in Madison.

Federal Practitioner : for the Health Care Professionals of the VA, Dod, and PHS
|December 17, 2020
PubMed

Insights

Continued oritavancin dosing is safe and effective for difficult Gram-positive infections. This includes challenging bacteria like methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Antimicrobial Therapy

Background:

  • Complicated Gram-positive infections pose significant treatment challenges.
  • Emerging antibiotic resistance, including MRSA and VRE, necessitates novel therapeutic strategies.
  • Oritavancin is a lipoglycopeptide antibiotic with activity against Gram-positive pathogens.

Purpose of the Study:

  • To evaluate the safety and efficacy of continued oritavancin dosing.
  • To assess the role of oritavancin in managing complicated Gram-positive infections.

Main Methods:

  • Review of retrospective and cohort analyses.
  • Examination of clinical data on oritavancin treatment regimens.
  • Analysis of patient outcomes and adverse events.

Main Results:

  • Continued oritavancin dosing demonstrated a favorable safety profile.
  • Efficacy was observed in treating complicated Gram-positive infections.
  • Specific pathogens like methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) were addressed.

Conclusions:

  • Sustained oritavancin administration is a viable option for complicated Gram-positive infections.
  • Oritavancin offers a safe and effective therapeutic choice against resistant strains.
  • Further research may explore optimal dosing strategies for oritavancin.

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