Pharmacist Consult Reports to Support Pharmacogenomics Report Interpretation.

Area of Science:

• Pharmacogenomics (PGx)
• Clinical Pharmacy
• Personalized Medicine

Background:

• Pharmacogenomics implementation often involves pharmacists, but standard reports lack patient-specific context.
• Physician inexperience with PGx interpretation is a barrier to widespread clinical adoption.
• Current PGx reporting often overlooks concurrent disease states and medication use.

Purpose of the Study:

• To describe how pharmacists can personalize pharmacogenomics information for individual patients.
• To identify clinical recommendations by integrating PGx data with patient-specific factors.
• To evaluate the role of pharmacists in enhancing PGx utility.

Main Methods:

• Secondary analysis of a study on genetic biomarkers for opioid addiction risk.
• Descriptive analysis of pharmacist consult reports with individualized, patient-level recommendations.
• Testing of 60 common PGx targets in patients with chronic pain or opioid use disorder (OUD).

Main Results:

• PGx reports for 78.6% of patients had decision support flags for current medications.
• Pharmacists recommended prescription modifications for 53% of patients with actionable flags.
• 24.2% of flags had immediate clinical value; 86% received non-PGx related recommendations.

Conclusions:

• Pharmacogenomics data requires patient-specific context for effective pharmacotherapy personalization.
• Pharmacists streamline PGx reports and identify interventions by integrating patient data.
• Clinical pharmacist engagement can facilitate broader pharmacogenomics implementation.