Related Experiment Video
Updated: Nov 25, 2025

In vivo Assessment of Microtubule Dynamics and Orientation in Caenorhabditis elegans Neurons
Published on: November 20, 2021
Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity
Oliver R Wilkes1,2, Adrian W Moore1
1Laboratory for Neurodiversity, RIKEN Center for Brain Science, Wako-shi, Japan.
Abstract:
Dendrite and axon arbor wiring patterns determine the connectivity and computational characteristics of a neuron. The identities of these dendrite and axon arbors are created by differential polarization of their microtubule arrays, and their complexity and pattern are generated by the extension and organization of these arrays. We describe how several molecularly distinct microtubule organizing center (MTOC) mechanisms function during neuron differentiation to generate and arrange dendrite and axon microtubules. The temporal and spatial organization of these MTOCs generates, patterns, and diversifies arbor wiring.
Related Concept Videos
Assembly of Complex Microtubule Structures
Microtubule Formation
Spindle Assembly
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
Microtubules in Signaling
The Mitotic Spindle
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
Polarity of the Cytoskeleton

