The distribution and regulation of aromatase activity in the central nervous system

Our data demonstrate that androgen-dependent AA is found in areas of the brain that are essential for the neuroendocrine control of gonadotropin secretion and sexual behavior. However, until we know more about the neurons that contain AA, e.g., whether they are peptidergic or catecholaminergic, we can not speculate about the neuronal functions that depend on local estrogen formation. In fact, the association of AA with neurons and not glia has only recently been demonstrated. That estrogens and androgens synergize in the regulation of various neuroendocrine functions has been known for many years, but an explanation of the synergism at the cellular level was not available. One explanation for this synergism may lie in our recent observation that the administration of exogenous estradiol to castrated rats increases androgen-receptor concentrations in specific brain nuclei. Perhaps locally formed estrogens work in a similar fashion to regulate androgen receptors in the brain of the intact male.