Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

14.2K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.2K
Decreased Body Temperature01:29

Decreased Body Temperature

829
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
829
Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

8.0K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
8.0K
Mechanism of heat transfer01:19

Mechanism of heat transfer

1.6K
Understanding heat transfer mechanisms is essential for understanding how our bodies maintain balance in different environmental conditions. When the environment is thermoneutral, the body is in a state of balance, neither using nor releasing energy to maintain its core temperature. However, when the environment is not thermoneutral, the body employs four heat transfer mechanisms to maintain homeostasis: conduction, convection, evaporation, and radiation. These mechanisms facilitate heat...
1.6K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

2.8K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
2.8K
Requirements for Human Life01:26

Requirements for Human Life

12.1K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
12.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi.

Cell reports·2026
Same author

Protein Profiling of Wild-Caught <i>Phlebotomus papatasi</i> in Morocco: First Observation of Nematodes in Moroccan Population of Sandflies.

Pathogens (Basel, Switzerland)·2025
Same author

Characterization of Gut Bacteria in Natural Populations of Sand Flies (<i>Diptera</i>: <i>Psychodidae</i>) from Endemic and Non-Endemic Areas of Leishmaniasis in Morocco.

Microorganisms·2025
Same author

<i>p</i>-Alkoxy-Substituted Anisomycins with Potent Anti-Trypanosomiasis Activity and Expanded Modes of Action.

Journal of medicinal chemistry·2025
Same author

Developing and validating a Bayesian clinical risk prediction model for three sexually transmitted infections in key populations from two Canadian provinces.

Sexually transmitted infections·2025
Same author

Unique <i>Leishmania mexicana</i> clones secrete populations of extracellular vesicles with unique protein profile and variable infectious capability.

Frontiers in cellular and infection microbiology·2024

Related Experiment Video

Updated: Nov 25, 2025

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

15.1K

Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?

Fiorella Vialard1, Martin Olivier1

  • 1Department of Microbiology and Immunology, Program in Infectious Diseases and Immunity in Global Health, The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.

Frontiers in Immunology
|December 17, 2020
PubMed
Summary

Housing laboratory rodents below their thermoneutral zone creates cold stress, impacting their immune systems and hindering the translatability of mouse models for human health. Adjusting housing temperatures to thermoneutrality can improve research accuracy.

Keywords:
body temperatureimmune functionsimmunityinfectious diseasesmetabolismmurine modelthermoneutrality

More Related Videos

Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions
07:54

Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions

Published on: March 9, 2021

3.2K
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.3K

Related Experiment Videos

Last Updated: Nov 25, 2025

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

15.1K
Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions
07:54

Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions

Published on: March 9, 2021

3.2K
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.3K

Area of Science:

  • Comparative physiology
  • Immunology
  • Translational medicine

Background:

  • Mouse models are crucial for human disease research, but results often fail to translate to human patients.
  • Laboratory rodents are typically housed below their thermoneutral zone, inducing chronic cold stress.
  • This housing condition significantly impacts rodent metabolism and immune function, creating a major translational gap.

Purpose of the Study:

  • To review the impact of thermoneutral housing on the rodent immune system.
  • To analyze how thermoneutrality affects various disease models in rodents.
  • To advocate for the use of thermoneutral housing to enhance the translatability of murine research.

Main Methods:

  • Literature review of studies comparing rodent housing at thermoneutrality versus traditional temperatures.
  • Analysis of data on metabolic and immune responses in rodents under different thermal conditions.
  • Synthesis of findings across diverse disease models, including obesity, cancer, cardiovascular diseases, autoimmune diseases, asthma, and Alzheimer's disease.

Main Results:

  • Thermoneutral housing alters rodent physiology, impacting immune responses and disease outcomes.
  • Specific diseases like cardiovascular and autoimmune conditions may be exacerbated, while asthma and Alzheimer's may be alleviated.
  • Changes in gut microbiome composition are observed under thermoneutral conditions.
  • The effects on infectious diseases can be either exacerbating or alleviating, depending on the pathogen and model.

Conclusions:

  • Housing temperature is a critical variable affecting the validity of rodent disease models.
  • Implementing thermoneutral housing conditions can significantly improve the translational capacity of research findings.
  • Researchers should consider thermoneutral housing to refine murine models and bridge the gap between preclinical data and human health applications.