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"Turn-On" Fluorescent Biosensors for High Selective and Sensitive Detection of Al3+ Ion
Pengfei Wang1, Lijie Liu1, Fanda Meng2
1Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China.
Abstract:
A series of new compounds (1-4) based on pyrrole hydrazone Schiff bases were designed and synthesized. The interactions of these new compounds with metal ions and their fluorescent recognition were investigated. All compounds showed "turn-on" fluorescence in the presence of Al3+ in aqueous solution. Their sensing behaviors with Al3+ were studied using photophysical experiments, ESI-MS spectrometry analysis, 1H NMR titration, and DFT calculation. The detection limits of 1-4 for the analysis of Al3+ were found to reach a 10-8 M level in aqueous solution, which are far lower than the WHO guidelines for drinking water (7.41 mM for Al3+). A high selectivity test paper has been fabricated for Al3+ detection based on sensor 3. Theoretical calculations (DFT) have been carried out to elucidate the configuration of 1-4 and their Al complexes and rationalize experimental absorption data.
