Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peptic Ulcer Disease IV: Management

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...

Hand hygiene

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Strengths and Limitations of Sodium Lauryl Sulfate as an Irritant Control in Patch Testing.

Contact dermatitis·2025

Same author

The Retinoid Tamibarotene Aggravates Skin Inflammation in a Model of Bullous Pemphigoid-like Epidermolysis Bullosa Acquisita.

Cells·2025

Same author

Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression.

Frontiers in immunology·2025

Same author

Allergen immunotherapy-induced anaphylaxis: Data from the European Anaphylaxis Registry.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025

Same author

A phase 2 randomized trial of safety and pharmacokinetics of IgPro20 and IgPro10 in patients with diffuse cutaneous systemic sclerosis.

Rheumatology (Oxford, England)·2025

Same author

Anaphylaxis definition, overview, and clinical support tool: 2024 consensus report-a GA<sup>2</sup>LEN project.

The Journal of allergy and clinical immunology·2025

Search research articles

Related Experiment Video

Updated: Nov 25, 2025

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Therapy Changes During Pemphigus Management: A Retrospective Analysis.

Roberta Scarpone¹, Wojciech Francuzik¹, Margitta Worm¹

¹Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Frontiers in Medicine

|December 17, 2020

Summary

This summary is machine-generated.

Pemphigus treatment requires multiple changes, averaging four regimens over two years, to achieve disease control. Rituximab showed high remission rates in refractory cases, highlighting the need for personalized therapy prediction.

Keywords:

autoantibodies pemphigus retrospective study therapy changes treatment

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Related Experiment Videos

Last Updated: Nov 25, 2025

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Autoimmune Diseases
Immunology

Background:

Pemphigus is a rare autoimmune blistering disease with variable patient responses to treatment.
Achieving disease control often necessitates multiple therapeutic adjustments due to efficacy or side effects.

Purpose of the Study:

To analyze pemphigus patient treatment courses and clinical responses.
To evaluate the impact of therapy changes on disease control and outcomes.

Main Methods:

Retrospective analysis of 77 pemphigus patients.
Data collected included medication, dosage, disease activity, reasons for changes, and autoantibody levels.
Analysis of therapy modifications for insufficient effect or adverse events.

Main Results:

Disease control (almost clear/clear) was achieved in 86% of patients.
An average of 4 therapy regimens were used over 2 years (range: 1-18 changes).
Rituximab led to remission in 86% of 22 refractory patients; anti-desmoglein antibodies correlated with severity, not treatment changes.

Conclusions:

Individualized pemphigus therapy is challenging and time-consuming, often requiring numerous regimen changes.
Predictive parameters are needed to identify optimal and safe treatment strategies for individual patients.
Rituximab is effective for refractory pemphigus.