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Updated: Nov 25, 2025

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages
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Does Malaria Cause Diarrhoea? A Systematic Review.

Isatou C M Sey1, Ajoke M Ehimiyein1,2, Christian Bottomley3

  • 1Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Frontiers in Medicine
|December 17, 2020
PubMed
Summary
This summary is machine-generated.

Malaria infection can cause diarrhea, with estimates ranging from 1.6% to 44% in malaria patients and 5% to 42% in diarrhea patients. However, more research is needed to confirm this link.

Keywords:
coinfectiondiarrhoeaintestinemalariaplasmodiumsystematic review

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Area of Science:

  • Infectious Diseases
  • Tropical Medicine
  • Gastroenterology

Background:

  • Malaria is a severe febrile illness with potential fatal outcomes.
  • Malaria is a known risk factor for invasive bacterial infections, particularly non-Typhoidal Salmonella (NTS).
  • While animal models suggest gut dysbiosis contributes to NTS risk in malaria, clinical evidence is limited.

Conclusions:

  • The relationship between malaria and gastrointestinal disturbance, specifically diarrhea, remains unclear due to limited and inconsistent clinical evidence.
  • Varied definitions of diarrhea and lack of robust study designs (case-control, longitudinal) hinder definitive conclusions.
  • Further well-designed studies are essential to accurately determine the prevalence and significance of intestinal manifestations in malaria.