Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer Imaging
William M MacCuaig1, Meredith A Jones1, Oshaani Abeyakoon1
1Stephenson Cancer Center (W.M.M., M.A.J., L.R.M.) and Department of Surgery (L.R.M.), University of Oklahoma, 755 Research Parkway, 1 Medical Center Blvd, Oklahoma City, OK 73104; Department of Biomedical Engineering, University of Oklahoma, Norman, Okla (W.M.M., M.A.J., L.R.M.); and Department of Interventional Radiology, University College Hospital London, London, England (O.A.).
Abstract:
The use of optoacoustic imaging takes advantage of the photoacoustic effect to generate high-contrast, high-resolution medical images at penetration depths of up to 5 cm. Multispectral optoacoustic tomography (MSOT) is a type of optoacoustic imaging system that has seen promising preclinical success with a recent emergence into the clinic. Multiwavelength illumination of tissue allows for the mapping of multiple chromophores, which are generated endogenously or exogenously. However, translation of MSOT to the clinic is still in its preliminary stages. For successful translation, MSOT requires refinement of probes and data-acquisition systems to tailor to the human body, along with more intuitive, real-time visualization settings. The possibilities of optoacoustic imaging, namely MSOT, in the clinic are reviewed here. ©RSNA, 2020.
