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Diverse Functional Autoantibodies in Patients with COVID-19
Eric Y Wang1, Tianyang Mao1, Jon Klein1
1Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Medrxiv : the Preprint Server for Health Sciences
|December 17, 2020
Summary
COVID-19 patients show increased autoantibodies against immune proteins, impacting immune function and disease severity. These findings highlight a pathological role for exoproteome-directed autoantibodies in COVID-19 progression.
Area of Science:
- Immunology
- Virology
- Pathology
Background:
- COVID-19 presents diverse clinical phenotypes driven by immune dysregulation.
- While innate immune activation is known, the role of autoantibodies in COVID-19 progression is unclear.
Conclusions:
- Exoproteome-directed autoantibodies play a pathological role in COVID-19.
- These autoantibodies contribute to immune dysfunction and are associated with clinical outcomes.
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