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Updated: Nov 25, 2025

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Heart rate variability as an autonomic biomarker in ischemic stroke
Natalia Buitrago-Ricaurte1, Fátima Cintra2, Gisele Sampaio Silva1
1Universidade Federal de São Paulo, Department of Neurology, São Paulo SP, Brazil.
Abstract:
Stroke is one of the leading causes of mortality and disability worldwide. Autonomic dysfunction after ischemic stroke is frequently associated with cardiac complications and high mortality. The brain-heart axis is a good model for understanding autonomic interaction between the autonomic central network and the cardiovascular system. Heart rate variability (HRV) analysis is a non-invasive approach for understanding cardiac autonomic regulation. In stroke patients, HRV parameters are altered in the acute and chronic stages of the disease, having a prognostic value. In this literature review we summarize the main concepts about the autonomic nervous system and HRV as autonomic biomarkers in ischemic stroke.
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