Related Experiment Video
Updated: Nov 25, 2025
07:40
Multi-Modal Home Sleep Monitoring in Older Adults
Published on: January 26, 2019
7.9K
Subjective sleep parameters in prodromal Alzheimer's disease: a case-control study
Conrado R Borges1, Ronaldo D Piovezan2, Dalva R Poyares2
1Departamento de Neurologia, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999)
|December 17, 2020
Summary
Older adults with amyloid plaques experienced longer time in bed and lower sleep efficiency. Those with multiple-domain mild cognitive impairment (MCI) reported poorer sleep quality and shorter sleep duration.
Area of Science:
- Neurology
- Sleep Medicine
- Biomarkers
Background:
- Alzheimer's disease (AD) dementia is associated with impaired sleep.
- Sleep characteristics in early-stage AD and their association with biomarkers are not well understood.
Purpose of the Study:
- To investigate subjective sleep characteristics in non-demented older adults.
- To compare sleep profiles with amyloid-beta (Aβ) biomarker status.
Main Methods:
- 30 non-demented participants (age ≥ 60) underwent [11C]PiB-PET-CT scans.
- Neuropsychological evaluations and standardized sleep assessments (Pittsburgh Sleep Quality Index, Epworth Sleep Scale) were performed.
Main Results:
- Individuals with positive amyloid scans reported longer time in bed (p=0.024) and reduced sleep efficiency (p=0.05).
- Multiple-domain mild cognitive impairment (MCI) was linked to shorter total sleep time (p=0.034) and worse sleep quality (p=0.027) compared to single-domain MCI.
Conclusions:
- Amyloid positivity in older adults correlates with increased time in bed and decreased sleep efficiency, irrespective of cognitive status.
- Multiple-domain MCI is associated with poorer self-reported sleep duration and quality.
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