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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

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[Autosomal dominant polycystic kidney disease : a pediatric perspective]

A Dachy1, L Collard1,2, J M Krzesinski3

  • 1Service de Pédiatrie, CHU Liège, Belgique.

Revue Medicale De Liege
|December 17, 2020
PubMed

Insights

Polycystic kidney disease (PKD) is a common inherited kidney disorder. Identifying early predictive markers in children is crucial for slowing disease progression and preserving kidney function.

Area of Science:

  • Nephrology
  • Genetics
  • Pediatrics

Background:

  • Polycystic kidney disease (PKD) is the most common inherited kidney disease, typically presenting in adulthood.
  • Renal cyst development begins in childhood, yet screening protocols for pediatric patients remain undefined.
  • Tolvaptan is an approved treatment for slowing PKD progression in adults.

Purpose of the Study:

  • To investigate the need for early predictive markers of renal function decline in pediatric patients with PKD.
  • To explore potential early indicators for slowing the progression of polycystic kidney disease in children.

Main Methods:

  • Review of current scientific literature on PKD progression and pediatric screening.
  • Analysis of animal model studies demonstrating the impact of early intervention on cyst growth.
  • Examination of the efficacy of tolvaptan in adult PKD patients.

Main Results:

  • PKD cyst formation starts early in life, suggesting a window for intervention.
  • Animal models indicate that inhibiting cyst growth can decelerate renal function decline.
  • Current adult treatments like tolvaptan highlight the potential for therapeutic strategies in slowing PKD.

Conclusions:

  • Early identification of predictive markers in children is essential for proactive PKD management.
  • Developing pediatric screening strategies could significantly impact long-term renal health outcomes.
  • Further research is warranted to establish consensus on pediatric PKD screening and early intervention.

Keywords:
ChildhoodProgression markerTreatmentAutosomal dominant polycystic kidney disease

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