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Updated: Nov 25, 2025

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An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
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[Postoperative opioid overdose due to patient-controlled analgesia by proxy]
S van Heijster1, J Janssen1, E Sarton1
1LUMC, afd. Anesthesiologie, Leiden.
Nederlands Tijdschrift Voor Geneeskunde
|December 17, 2020
Summary
Patient-controlled analgesia (PCA) can be complicated by PCA by proxy, where a caregiver administers medication. A language barrier contributed to a case of PCA by proxy in a postoperative patient receiving morphine.
Area of Science:
- Anesthesiology
- Pharmacology
- Patient Safety
Background:
- Patient-controlled analgesia (PCA) is a common method for managing postoperative pain.
- Intravenous morphine PCA is frequently used for effective pain relief after surgery.
- PCA use is associated with potential complications, including respiratory depression.
Observation:
- A 73-year-old Somalian male patient developed unresponsiveness after abdominal surgery.
- The patient was receiving intravenous morphine PCA, with his son acting as interpreter.
- The patient's son admitted to operating the PCA device for the patient.
Findings:
- The patient experienced respiratory depression, indicated by low oxygen saturation.
- Naloxone administration was required to reverse the opioid effects.
- PCA by proxy, facilitated by a language barrier, was identified as the cause.
Implications:
- PCA by proxy poses significant risks, including overdose and respiratory compromise.
- Healthcare providers must address language barriers and health literacy in PCA management.
- Implementing robust safety protocols is crucial to prevent PCA-related adverse events.
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