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[Mortality and re-admission after hospitalization with COVID-19]
Wouter T Leijte1, Nicolaas M M Wagemaker1, Tom D A van Kraaij2
1Zuyderland Medisch Centrum, afd. Longziekten, Sittard/Heerlen.
Insights
One in six patients hospitalized with COVID-19 experienced death or readmission post-discharge. This highlights ongoing patient vulnerability and the need for careful discharge planning and monitoring for coronavirus disease 2019 survivors.
Area of Science:
- Infectious Diseases
- Public Health
- Epidemiology
Background:
- Hospitalization for coronavirus disease 2019 (COVID-19) can lead to post-discharge complications.
- Understanding outcomes after COVID-19 hospitalization is crucial for patient management.
Purpose of the Study:
- To evaluate mortality rates and readmission characteristics following COVID-19 hospitalization.
- To identify risk factors associated with death and readmission after discharge.
Main Methods:
- Retrospective cohort study of 769 patients hospitalized with COVID-19.
- Analysis included in-hospital mortality, post-discharge mortality, and readmission rates.
- Regression analysis was used to determine risk factors for adverse outcomes.
Main Results:
- In-hospital mortality was 22.4%. Post-discharge mortality was 6.4% and the readmission rate was 11.7%.
- Leading causes for readmission included respiratory insufficiency, thrombotic events, and chronic comorbidities.
- Older age, delirium during hospitalization, male sex, discharge to long-term care, and COPD were associated with increased mortality or readmission.
Conclusions:
- Approximately 1 in 6 COVID-19 patients faced death or readmission after discharge.
- This indicates a sustained vulnerability in COVID-19 survivors, necessitating informed discharge strategies and ongoing monitoring.
- Findings support the need for proactive hospital capacity planning and patient follow-up protocols.
Objective:
Hospitalization for corona virus disease 2019 (COVID-19) may be followed by complications after discharge. We aimed to evaluate mortality, readmission rate, and readmission characteristics after hospitalization with COVID-19.
Design:
A retrospective cohort study METHODS: Inclusion of all patients hospitalized for COVID-19 between March 1, 2020, and June 1, 2020 in Zuyderland Medical Centre, The Netherlands. Main outcome measures were mortality and readmission after hospitalization. Univariate and multivariate regression analysis were performed to identify risk factors for death and readmission.
Results:
A total of 769 patients hospitalized with COVID-19 (mean age 70 ± 14 years; 39% female) were included in the study. In-hospital mortality was 22.4% , as such 596 patients were discharged alive and followed after discharge with a median of 80 days (IQR 66-91). Total mortality after discharge was 6.4% (n=38) and readmission rate was 11.7% (n=70). Main reasons for readmission were respiratory insufficiency (31%), arterial and venous thrombotic events (16%) or related to a chronic comorbidity (14%). Mortality rates were higher in older patients and patients who experienced delirium during hospital stay. Risk factors for readmission were male sex, discharge to a long-term care facility and COPD.
Conclusion:
1 out of 6 COVID-19 positive patients died or was readmitted after discharge. This shows an ongoing vulnerability of COVID-19 patients. Physicians and policy makers should consider this high rate when making decisions on discharge, hospital-capacity planning, and patient monitoring after discharge.
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