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Updated: Nov 25, 2025

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Published on: March 1, 2015
[Labium majus enlargement in a 6-year old girl: benign or alarming?]
Scott J Brugmans1,2, Fia Ten Brink3, Peggy M A J Geomini1
1Máxima Medisch Centrum, afd. Gynaecologie-Verloskunde, Veldhoven.
Abstract:
A 6-year old girl was referred because she had a painless enlarged left labium majus. There were no further symptoms. Ultrasound and MRI revealed no hernias, malignancy or cystic abnormalities. We diagnosed CALME, Childhood Asymmetry Labium Majus Enlargement, a non-neoplastic expansion of normal vulvar tissue in response to hormonal changes. Expectant management is preferred.
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