Improved visuospatial neglect after tDCS and computer-assisted cognitive training in Posterior Cortical Atrophy: a...

Area of Science:

• Neuroscience
• Rehabilitation Medicine
• Cognitive Neurology

Background:

• Visuospatial neglect (VN) is a common and debilitating symptom in Posterior Cortical Atrophy (PCA).
• Effective rehabilitation strategies for VN in neurodegenerative disorders like PCA are crucial but limited.
• Current treatments often focus on compensatory strategies, with less emphasis on restorative approaches.

Purpose of the Study:

• To investigate the efficacy of computer-assisted cognitive training (CCT) for improving left-sided VN symptoms in a patient with PCA.
• To evaluate the added benefit of anodal transcranial direct-current stimulation (A-tDCS) over the right posterior parietal cortex when combined with CCT.
• To explore a novel, technology-driven rehabilitation approach for VN in a neurodegenerative context.

Main Methods:

• A single-case study design was employed.
• The study utilized the digital ReMoVES platform for both assessment and training of VN.
• Interventions included CCT alone and CCT coupled with multiple sessions of A-tDCS targeting the right posterior parietal cortex.

Main Results:

• The patient demonstrated significant improvement in left-sided VN symptoms following the combined CCT and A-tDCS intervention.
• The digital ReMoVES platform facilitated objective assessment and targeted cognitive training.
• This represents the first investigation into this combined therapeutic approach for VN in PCA.

Conclusions:

• The combination of CCT and A-tDCS shows promise as a viable rehabilitation strategy for visuospatial neglect in Posterior Cortical Atrophy.
• This approach offers a potential avenue for restorative treatment in neurodegenerative conditions.
• Further research with larger sample sizes is warranted to confirm these preliminary findings.