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Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
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Sis1 delivers the State of the Union
1Department of Biochemistry, Stanford University, Stanford, CA.
The Journal of Cell Biology
|December 17, 2020
Abstract:
The heat shock response (HSR) is a gene expression program that protects cells from heat and proteotoxic stressors. In this issue, Feder et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202005165) show that subcellular relocalization of the cochaperone Sis1 drives the HSR by de-suppressing the transcription factor Hsf1.
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