Effects of artery input function on dynamic contrast-enhanced MRI for determining grades of gliomas

To evaluate the effect of artery input function (AIF) derived from different arteries for pharmacokinetic modeling on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters in the grading of gliomas.

49 patients with pathologically confirmed gliomas were recruited and underwent DCE-MRI. A modified Tofts model with different AIFs derived from anterior cerebral artery (ACA), ipsilateral and contralateral middle cerebral artery (MCA) and posterior cerebral artery (PCA) was used to estimate quantitative parameters such as K^trans (volume transfer constant) and V_e (fractional extracellular-extravascular space volume) for distinguishing the low grade glioma from high grade glioma. The K^trans and V_e were compared between different arteries using Two Related Samples Tests (TRST) (i.e. Wilcoxon Signed Ranks Test). In addition, these parameters were compared between the low and high grades as well as between the grade II and III using the Mann-Whitney U-test. A p-value of less than 0.05 was regarded as statistically significant.

All the patients completed the DCE-MRI successfully. Sharp wash-in and wash-out phases were observed in all AIFs derived from the different arteries. The quantitative parameters (K^trans and V_e) calculated from PCA were significant higher than those from ACA and MCA for low and high grades, respectively (p < 0.05). Despite the differences of quantitative parameters derived from ACA, MCA and PCA, the K^trans and V_e from any AIFs could distinguish between low and high grade, however, only K^trans from any AIFs could distinguish grades II and III. There was no significant correlation between parameters and the distance from the artery, which the AIF was extracted, to the tumor.

Both quantitative parameters K^trans and V_e calculated using any AIF of ACA, MCA, and PCA can be used for distinguishing the low- from high-grade gliomas, however, only K^trans can distinguish grades II and III.

We sought to assess the effect of AIF on DCE-MRI for determining grades of gliomas. Both quantitative parameters K^trans and V_e calculated using any AIF of ACA, MCA, and PCA can be used for distinguishing the low- from high-grade gliomas.