Related Experiment Video

Updated: Nov 25, 2025

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

333

Dose-response relationship between blood pressure and intracranial atherosclerotic stenosis

Hong-Qi Li1, Xun Wang1, Hui-Fu Wang2

  • 1Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Atherosclerosis
|December 17, 2020
PubMed

Insights

Elevated blood pressure significantly increases the risk of intracranial atherosclerotic stenosis (ICAS). Higher systolic and pulse pressures are linked to a greater ICAS burden in the Chinese population.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Public Health

Background:

  • Intracranial atherosclerotic stenosis (ICAS) is a significant cause of stroke.
  • Understanding the relationship between blood pressure and ICAS is crucial for prevention strategies.

Purpose of the Study:

  • To investigate the association between blood pressure levels and the risk and burden of ICAS.
  • To analyze these associations within the Chinese population.

Main Methods:

  • A large-scale, multi-center, case-control study was conducted.
  • 1055 ICAS patients and 1296 controls were analyzed.
  • Intracranial arteries were evaluated using advanced imaging techniques (MRA, CTA, DSA).

Main Results:

  • Increased systolic, diastolic, and pulse pressure were significantly associated with higher odds of ICAS.
  • Each 10 mmHg increase in systolic, diastolic, and pulse pressure correlated with a 32%, 28%, and 35% increased odds of ICAS, respectively.
  • Higher systolic and pulse pressures were also linked to an increased ICAS burden.

Conclusions:

  • Blood pressure components (systolic, diastolic, pulse pressure) show a dose-response relationship with ICAS risk.
  • Elevated systolic and pulse pressures contribute to a greater ICAS burden, highlighting the importance of blood pressure management.
Abstract

Keywords:
Blood pressureHypertensionIntracranial atherosclerosis

More Related Videos

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.3K
Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries08:21

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Published on: April 1, 2019

7.4K

Related Concept Videos

Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
4.5K
Dose-Response Relationship: Potency and Efficacy01:22

Dose-Response Relationship: Potency and Efficacy

The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
6.0K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
1.1K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
209
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
1.2K