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Published on: April 15, 2016
Continuous Renal Replacement Therapy with oXiris® Membrane in Severe Ebstein-Barr Virus-Mediated Hemophagocytic
Karla N Samman1, Hussein Baalbaki1, Josée Bouchard1
1Department of Medicine, Hôpital du Sacré-Cœur de Montréal, Université de Montréal, Montreal, Québec, Canada.
Abstract:
Hemophagocytic lymphohistiocytosis (HLH), a life-threatening disease with uncontrolled immune activation and inflammatory reaction, often leads to a deadly cytokine storm. In severe Ebstein-Barr virus-triggered HLH receiving standard immunosuppression, continuous renal replacement therapy (CRRT) with oXiris® blood purification membrane resulted in a timely reduction of inflammatory markers and discontinuation of vasopressors. To our knowledge, this is the first report of successful use of the oXiris® membrane in HLH.
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