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Prognostic Value of Estimated Glomerular Filtration Rate 3-6 Months after Percutaneous Coronary Intervention

Won Jik Lee1, Dong-Bin Kim2, Sung-Ho Her3

  • 1Department of Cardiology, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Republic of Korea.

Cardiorenal Medicine
|December 17, 2020
PubMed

Insights

Follow-up renal function after percutaneous coronary intervention (PCI) is a strong predictor of patient outcomes. Post-PCI estimated glomerular filtration rate (eGFR) is more accurate for predicting outcomes than pre-PCI eGFR.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Statistics

Background:

  • The prognostic significance of follow-up renal function in patients undergoing percutaneous coronary intervention (PCI) is not well-established.
  • This study aimed to clarify the prognostic implications of renal function changes after PCI.

Purpose of the Study:

  • To investigate the prognostic value of estimated glomerular filtration rate (eGFR) changes after PCI.
  • To compare the predictive accuracy of pre-PCI and post-PCI eGFR for clinical outcomes.

Main Methods:

  • A drug-eluting stent registry cohort of 4,899 patients was analyzed.
  • Patients were stratified into four groups based on pre-PCI and 3-6 month follow-up eGFR status (normal or abnormal).
  • Three-year mortality rates were compared across the four groups.

Main Results:

  • Significant differences in 3-year mortality were observed between groups (2%, 11%, 4%, 9% for groups 1-4, respectively).
  • Worsening renal function post-PCI was associated with a poorer prognosis compared to recovery of renal function.
  • A prediction model incorporating follow-up eGFR demonstrated superior predictive power for clinical outcomes compared to pre-PCI eGFR.

Conclusions:

  • Post-PCI eGFR is a more accurate predictor of patient outcomes than pre-PCI eGFR.
  • Monitoring renal function after PCI is crucial for risk stratification and management.
Abstract

Keywords:
Drug-eluting stentPrognosisRenal insufficiency

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