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Mechanisms of Retrovirus-induced Cancers

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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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Human Papillomavirus and Cancers.

Maria Lina Tornesello1, Franco M Buonaguro1

  • 1Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", via Mariano Semmola, 80131 Naples, Italy.

Cancers
|December 18, 2020
PubMed
Summary
This summary is machine-generated.

Persistent infection with oncogenic human papillomaviruses (HPVs) causes most cervical cancers and other malignancies. Understanding HPV

Area of Science:

  • Oncology
  • Virology
  • Epidemiology

Background:

  • Persistent infection with oncogenic human papillomaviruses (HPVs) is a primary driver of cervical cancer.
  • HPVs also contribute significantly to other cancers of the squamous epithelia in the anogenital and head and neck regions.

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