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Cyclodextrin-Based Functional Glyconanomaterials.

Gonzalo Rivero-Barbarroja1, Juan Manuel Benito2, Carmen Ortiz Mellet1

  • 1Department of Organic Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain.

Nanomaterials (Basel, Switzerland)
|December 18, 2020
PubMed
Summary

Cyclodextrins (CDs) are versatile nanoscaffolds for drug delivery. Advanced functionalization and click chemistry enable novel glyconanomaterials for improved drug loading and understanding protein interactions.

Keywords:
cyclodextrinsdrug deliverygene deliveryglyconanomaterialsglyconanoparticlesglycopolymersglycotargetingmultivalencyself-assemblysupramolecular nanomaterials

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Carbohydrate Chemistry

Background:

  • Cyclodextrins (CDs) are widely used in pharmaceuticals for their biocompatibility and inclusion properties, aiding in drug formulation and pharmacokinetics.
  • Recent advances in selective functionalization and click chemistry have transformed CDs into sophisticated nanoscaffolds.
  • CDs bridge the gap between glycobiology and nanotechnology, enabling new applications.

Purpose of the Study:

  • To review the advancements in cyclodextrin-based functional glyconanomaterials over the last decade.
  • To highlight the role of CDs in understanding glycan-protein interactions and improving nanomaterial properties.
  • To showcase the versatility of CDs in creating advanced nanostructures.

Main Methods:

  • Selective chemical functionalization of cyclodextrins.
  • "Click" chemistry for multiconjugation and assembly.
  • Host-guest complexation strategies for drug loading.
  • Self-assembly, template-assisted assembly, and covalent linkage of CD/glycan building blocks.

Main Results:

  • Development of precision chemical methods for CD functionalization.
  • Creation of diverse functional glyconanomaterials with tailored properties.
  • Enhanced understanding of multivalent glycodisplay and lectin interactions.
  • Improved drug-loading capacities and functional attributes of nanomaterials.

Conclusions:

  • Cyclodextrins are highly versatile building blocks for advanced glyconanomaterials.
  • Functionalized CDs offer powerful tools for drug delivery, diagnostics, and biomolecular interaction studies.
  • The integration of CDs into nanostructures opens new avenues in pharmaceutical and materials science.